Which of the following statements correctly describes hemoglobin carbonation?

Hemoglobin carbonation occurs primarily in the lungs and involves the binding of O2 to hemoglobin.

Hemoglobin carbonation occurs primarily in the tissues and involves the binding of O2 to hemoglobin.

Hemoglobin carbonation occurs primarily in the tissues and involves the binding of CO2 to hemoglobin.

Hemoglobin carbonation occurs primarily in the lungs and involves the binding of CO2 to hemoglobin.