Question 1

Which of the following best describes the location of peripheral membrane proteins?

Accepted Answer

Located on the periphery of the lipid bilayer, associated with polar head groups

Question 2

Peripheral membrane proteins are most commonly associated with the membrane through which type of interaction?

Accepted Answer

Hydrogen bonding and electrostatic interactions

Question 3

Which treatment is most likely to release peripheral membrane proteins from the membrane?

Accepted Answer

Treatment with high salt or changes in pH

Question 4

Which of the following statements is TRUE regarding integral membrane proteins?

Accepted Answer

They span the lipid bilayer and require detergents for removal

Question 5

A scientist is studying a membrane protein that can be released by treating the membrane with a mild salt solution. What type of protein is this most likely to be?

Accepted Answer

Peripheral membrane protein

Question 6

Which of the following is NOT a characteristic of peripheral membrane proteins?

Accepted Answer

They span the lipid bilayer

Question 7

Which of the following is a function of peripheral membrane proteins?

Accepted Answer

Facilitating cell signaling by acting as enzymes or structural components

Question 8

Which of the following best explains why peripheral membrane proteins do NOT require detergents for removal from the membrane?

Accepted Answer

They are not embedded in the hydrophobic core of the membrane

Question 9

Which of the following equations best represents the electrostatic interaction between a peripheral membrane protein and the membrane surface?

Accepted Answer

$$F = k \frac{q_1$ q_2$}{r^2$}$$

Question 10

A mutation causes a peripheral membrane protein to lose its ability to form hydrogen bonds. What is the most likely consequence?

Accepted Answer

The protein will have reduced affinity for the membrane surface

Question 11

Which of the following statements about amphipathic molecules is correct?

Accepted Answer

They contain both hydrophilic and hydrophobic regions

Question 12

Which of the following is most likely to occur if a cell is treated with a detergent?

Accepted Answer

Integral membrane proteins will be solubilized

Question 13

Which of the following is a distinguishing feature of integral membrane proteins compared to peripheral membrane proteins?

Accepted Answer

Integral membrane proteins span the lipid bilayer

Question 14

A researcher labels all proteins that can be removed from the membrane by high salt concentrations. Which type of proteins will be labeled?

Accepted Answer

Peripheral membrane proteins

Question 15

Which of the following is NOT a method by which peripheral membrane proteins associate with the membrane?

Accepted Answer

Spanning the lipid bilayer

Question 16

Which of the following best describes the effect of amphipathic molecules on membrane structure?

Accepted Answer

They help maintain membrane fluidity by interacting with both hydrophilic and hydrophobic regions

Question 17

Which of the following is a common misconception about peripheral membrane proteins?

Accepted Answer

They are embedded within the hydrophobic core of the membrane

Question 18

Which of the following is most likely to be true for a protein that acts as an enzymatic catalyst on the membrane surface?

Accepted Answer

It is a peripheral membrane protein

Question 19

Which of the following is the best explanation for why peripheral membrane proteins do not span the lipid bilayer?

Accepted Answer

They lack hydrophobic regions necessary for insertion into the bilayer

Question 20

Which of the following is a likely consequence of disrupting electrostatic interactions between a peripheral membrane protein and the membrane?

Accepted Answer

The protein will dissociate from the membrane surface

Peripheral Membrane Proteins and Membrane Structure

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