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Multiple Choice
What is the relationship between GLUT4 and insulin signaling in animal cells?
A
GLUT4 is an enzyme that breaks down insulin in the cytoplasm.
B
GLUT4 is a transcription factor activated by insulin to increase gene expression.
C
GLUT4 is a receptor that binds directly to insulin on the cell surface.
D
GLUT4 is a glucose transporter that is translocated to the cell membrane in response to insulin signaling.
Verified step by step guidance
1
Understand the role of GLUT4: GLUT4 is a glucose transporter protein found in animal cells, specifically in tissues like muscle and fat. It facilitates the uptake of glucose from the bloodstream into cells.
Learn about insulin signaling: Insulin is a hormone that regulates glucose levels in the blood. When insulin binds to its receptor on the cell surface, it triggers a signaling cascade inside the cell.
Explore the connection between insulin and GLUT4: Insulin signaling leads to the activation of intracellular pathways, such as the PI3K-Akt pathway, which ultimately causes GLUT4-containing vesicles to move toward the cell membrane.
Understand translocation: Once the GLUT4 vesicles reach the cell membrane, GLUT4 is inserted into the membrane, allowing glucose to be transported into the cell from the extracellular space.
Clarify the correct answer: GLUT4 is not an enzyme, transcription factor, or receptor. It is a glucose transporter that is translocated to the cell membrane in response to insulin signaling, enabling glucose uptake into the cell.