Multiple Choice
What effect can ATP-dependent chromatin remodeling have on transcription?
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16. Regulation of Expression
Eukaryotic Chromatin Modifications
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What is the primary role of DNA methylation in eukaryotes?
A
To activate gene expression
B
To facilitate DNA replication
C
To increase chromatin accessibility
D
To silence gene expression
Verified step by step guidance1
Understand that DNA methylation is a biochemical process involving the addition of a methyl group to the DNA molecule, typically at cytosine bases.
Recognize that in eukaryotes, DNA methylation primarily occurs at CpG sites, where a cytosine nucleotide is followed by a guanine nucleotide.
Learn that DNA methylation is associated with the repression of gene expression. When methyl groups are added to DNA, they can inhibit the binding of transcription factors and other proteins necessary for gene expression.
Note that methylation can lead to the formation of a more compact chromatin structure, known as heterochromatin, which is less accessible to the transcriptional machinery, thereby silencing gene expression.
Conclude that the primary role of DNA methylation in eukaryotes is to silence gene expression, which is crucial for processes like development, genomic imprinting, and X-chromosome inactivation.
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