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Multiple Choice
How could the loss of chromosomes contribute to the development of cancer?
A
Loss of chromosomes increases the rate of apoptosis in cancer cells.
B
Loss of chromosomes can result in the loss of tumor suppressor genes.
C
Loss of chromosomes enhances the immune response against cancer cells.
D
Loss of chromosomes can lead to the activation of oncogenes.
Verified step by step guidance
1
Understand the role of chromosomes in cell regulation: Chromosomes carry genes that are crucial for regulating cell growth and division. Among these genes are tumor suppressor genes, which help prevent uncontrolled cell growth.
Recognize the function of tumor suppressor genes: These genes produce proteins that can repair DNA damage, control cell division, and initiate apoptosis if necessary. Their loss can lead to unregulated cell proliferation.
Consider the impact of losing tumor suppressor genes: If chromosomes are lost, the genes they carry, including tumor suppressor genes, may also be lost. This can remove critical checks on cell growth, potentially leading to cancer development.
Explore the concept of oncogenes: Oncogenes are mutated forms of normal genes (proto-oncogenes) that promote cell division. While the loss of chromosomes typically results in the loss of genetic material, it can indirectly lead to oncogene activation if the balance of cell regulation is disrupted.
Summarize the connection to cancer: The loss of chromosomes can contribute to cancer by eliminating tumor suppressor genes, which normally inhibit cancerous growth, thereby allowing cells to proliferate uncontrollably.