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Multiple Choice
Which transcription factor binds directly to the TATA-box sequence during the initiation of transcription?
A
TFIIE
B
TFIIB
C
TFIIH
D
TFIID
Verified step by step guidance
1
Understand the role of transcription factors in the initiation of transcription. Transcription factors are proteins that help initiate and regulate the transcription of DNA into RNA.
Learn about the TATA-box, a DNA sequence found in the promoter region of genes. It is crucial for the formation of the transcription initiation complex.
Identify the transcription factor that binds directly to the TATA-box. This is typically the first step in forming the transcription initiation complex.
Recognize that TFIID is the transcription factor that binds directly to the TATA-box. TFIID is a complex that includes the TATA-binding protein (TBP) and several TBP-associated factors (TAFs).
Understand that the binding of TFIID to the TATA-box facilitates the recruitment of other transcription factors and RNA polymerase II to form the complete transcription initiation complex.