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Multiple Choice
Damage to DNA can halt the division of the cell at which stage of the cell cycle?
A
G2 checkpoint
B
G1 checkpoint
C
M phase
D
S phase
Verified step by step guidance
1
Understand the cell cycle: The cell cycle consists of several phases: G1, S, G2, and M. Each phase has specific functions and checkpoints to ensure proper cell division.
Identify the role of checkpoints: Checkpoints are control mechanisms in the cell cycle that ensure each phase is completed accurately before moving on to the next phase. The main checkpoints are G1, G2, and the M phase checkpoint.
Focus on the G1 checkpoint: The G1 checkpoint, also known as the restriction point, is crucial for assessing DNA integrity before the cell commits to DNA replication in the S phase. If DNA damage is detected, the cell can halt progression to repair the damage.
Consider the G2 checkpoint: The G2 checkpoint ensures that all DNA is replicated and undamaged before the cell enters mitosis (M phase). It is a secondary checkpoint for DNA damage but occurs after the S phase.
Evaluate the options: Given the role of the G1 checkpoint in assessing DNA damage before DNA replication, it is the most critical point for halting the cell cycle due to DNA damage, making it the correct answer.