Multiple Choice
Which of the following describes the normal function of the p53 gene product?
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11. Cell Division
Cancer
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Which of the following is true concerning cancer cells?
A
They have a limited number of cell divisions before entering senescence.
B
They can divide uncontrollably and evade normal cell cycle regulation.
C
They always undergo apoptosis when DNA damage is detected.
D
They require external growth factors to continue dividing.
Verified step by step guidance1
Understand the characteristics of cancer cells: Cancer cells are known for their ability to divide uncontrollably and evade normal cell cycle regulation. This is a key feature that distinguishes them from normal cells.
Review the concept of senescence: Normal cells have a limited number of divisions due to telomere shortening, leading to senescence. Cancer cells bypass this limit by activating mechanisms like telomerase, allowing indefinite division.
Examine apoptosis in cancer cells: Apoptosis is a programmed cell death mechanism triggered by DNA damage. Cancer cells often evade apoptosis by mutating genes like p53, which normally regulate this process.
Consider the role of growth factors: Normal cells require external growth factors to divide. Cancer cells can often produce their own growth signals or bypass the need for external factors, enabling continuous division.
Conclude the correct answer: Based on the above points, the statement 'They can divide uncontrollably and evade normal cell cycle regulation' is true concerning cancer cells, as it aligns with their defining characteristics.
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