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Multiple Choice
Which of the following events would be most likely to produce cells with several nuclei?
A
Premature entry into G1 phase
B
Inhibition of spindle fiber formation during metaphase
C
Failure of cytokinesis after mitosis
D
Failure of DNA replication during S phase
Verified step by step guidance
1
Understand the context: Mitosis is the process of nuclear division, and cytokinesis is the process of cytoplasmic division that follows mitosis. Together, they ensure that each daughter cell receives one nucleus and an appropriate amount of cytoplasm.
Analyze the event described: 'Failure of cytokinesis after mitosis' means that while the nucleus divides properly during mitosis, the cytoplasm does not divide, leaving multiple nuclei within a single cell.
Relate the event to the outcome: If cytokinesis fails, the cell will not split into two separate daughter cells. Instead, the cell will remain as one large cell containing multiple nuclei, as mitosis has already occurred.
Compare with other options: Premature entry into G1 phase, inhibition of spindle fiber formation during metaphase, or failure of DNA replication during S phase would not directly result in a multinucleated cell. These events would disrupt other aspects of the cell cycle but not lead to multiple nuclei in one cell.
Conclude: The most likely event to produce cells with several nuclei is the failure of cytokinesis after mitosis, as this directly prevents the physical separation of the nuclei into individual cells.