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Multiple Choice
Which of the following best describes the role of calcium ($\mathrm{Ca^{2+}}$) in synaptic activity?
A
It directly binds to neurotransmitters to activate postsynaptic receptors.
B
It triggers the fusion of synaptic vesicles with the presynaptic membrane, leading to neurotransmitter release.
C
It degrades neurotransmitters in the synaptic cleft.
D
It inhibits the generation of action potentials in the presynaptic neuron.
Verified step by step guidance
1
Step 1: Understand the context of the problem. The question is about the role of calcium ions ($\mathrm{Ca^{2+}}$) in synaptic activity, which is a key process in neuronal communication.
Step 2: Recall the process of synaptic transmission. When an action potential reaches the presynaptic terminal, voltage-gated calcium channels open, allowing $\mathrm{Ca^{2+}}$ to enter the presynaptic neuron.
Step 3: Recognize the role of $\mathrm{Ca^{2+}}$ in triggering synaptic vesicle fusion. The influx of $\mathrm{Ca^{2+}}$ binds to specific proteins (e.g., synaptotagmin) on the synaptic vesicles, which facilitates their fusion with the presynaptic membrane.
Step 4: Understand the result of vesicle fusion. This fusion releases neurotransmitters into the synaptic cleft, where they can bind to receptors on the postsynaptic membrane to propagate the signal.
Step 5: Eliminate incorrect options. $\mathrm{Ca^{2+}}$ does not directly bind to neurotransmitters, degrade them, or inhibit action potentials. Its primary role is to trigger vesicle fusion and neurotransmitter release.