Table of contents

1. Introduction to Biology2h 42m
2. Chemistry3h 37m
3. Water1h 26m
4. Biomolecules2h 23m
5. Cell Components2h 26m
6. The Membrane2h 31m
7. Energy and Metabolism2h 0m
8. Respiration2h 40m
9. Photosynthesis2h 49m
10. Cell Signaling59m
11. Cell Division2h 47m
12. Meiosis2h 0m
13. Mendelian Genetics4h 44m
14. DNA Synthesis2h 27m
15. Gene Expression3h 6m
16. Regulation of Expression3h 31m
17. Viruses37m
- Viruses
  37m
18. Biotechnology2h 58m
19. Genomics17m
- Genomes
  17m
20. Development1h 5m
21. Evolution3h 1m
22. Evolution of Populations3h 53m
23. Speciation1h 37m
24. History of Life on Earth2h 6m
25. Phylogeny2h 31m
26. Prokaryotes4h 59m
27. Protists1h 12m
28. Plants1h 22m
29. Fungi36m
- Fungi
  19m
- Fungi Reproduction
  17m
30. Overview of Animals34m
- Overview of Animals
  34m
31. Invertebrates1h 2m
32. Vertebrates50m
33. Plant Anatomy1h 3m
34. Vascular Plant Transport1h 2m
- Water Potential
  1h 2m
35. Soil37m
- Soil and Nutrients
  20m
- Nitrogen Fixation
  16m
36. Plant Reproduction47m
- Flowers
  33m
- Seeds
  14m
37. Plant Sensation and Response1h 9m
38. Animal Form and Function1h 19m
39. Digestive System1h 10m
- Digestion
  1h 3m
- Blood Sugar Homeostasis
  7m
40. Circulatory System1h 49m
41. Immune System1h 12m
42. Osmoregulation and Excretion50m
- Osmoregulation and Excretion
  50m
43. Endocrine System1h 4m
- Endocrine System
  1h 4m
44. Animal Reproduction1h 2m
- Animal Reproduction
  1h 2m
45. Nervous System1h 55m
- Neurons and Action Potentials
  1h 8m
- Central and Peripheral Nervous System
  46m
46. Sensory Systems46m
- Sensory System
  46m
47. Muscle Systems23m
- Musculoskeletal System
  23m
48. Ecology3h 11m
49. Animal Behavior28m
- Animal Behavior
  28m
50. Population Ecology3h 41m
51. Community Ecology2h 46m
52. Ecosystems2h 36m
53. Conservation Biology24m
- Conservation Biology
  24m

15. Gene Expression

Mutations

General Biology

15. Gene Expression

Mutations

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Multiple Choice

Which of the following mutations of the ras gene is most likely associated with cancer?

A mutation in the non-coding intronic region of the ras gene

A mutation that results in premature stop codon and loss of Ras protein

A silent mutation that does not change the amino acid sequence

A point mutation that leads to constitutive activation of Ras (e.g., G12V)

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Verified step by step guidance

Understand the role of the Ras protein: Ras is a GTPase that plays a critical role in cell signaling pathways, particularly those regulating cell growth and division. Mutations in Ras can lead to uncontrolled cell proliferation, which is a hallmark of cancer.

Analyze the types of mutations: Mutations can occur in different regions of a gene (coding or non-coding) and can have varying effects on protein function. For example, mutations in non-coding regions often do not affect protein function, while coding region mutations can alter the protein's structure or activity.

Evaluate the options: Consider the impact of each mutation described in the problem. A mutation in the non-coding intronic region is unlikely to affect Ras protein function. A premature stop codon would lead to a truncated, non-functional Ras protein, which is not associated with cancer. A silent mutation does not change the amino acid sequence and thus does not affect protein function.

Focus on the constitutive activation mutation: A point mutation, such as G12V, leads to constitutive activation of Ras. This means Ras remains permanently active, continuously signaling for cell growth and division, even in the absence of external signals. This uncontrolled signaling is strongly associated with cancer development.

Conclude the reasoning: Based on the analysis, the mutation most likely associated with cancer is the point mutation that leads to constitutive activation of Ras, as it directly contributes to the hallmark of cancer: uncontrolled cell proliferation.