Multiple Choice
Hemophilia is a recessive sex-linked genetic disorder. Which statement is true about this condition?
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13. Mendelian Genetics
Sex-Linked Inheritance
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Which individual is more likely to express an X-linked trait?
A
A male with one X chromosome
B
A male with two X chromosomes
C
A female with two X chromosomes
D
A female with one X chromosome
Verified step by step guidance1
Understand that X-linked traits are associated with genes found on the X chromosome. These traits are often recessive, meaning that two copies of the gene are typically needed for expression in females, who have two X chromosomes.
Recognize that males have one X and one Y chromosome. Therefore, if a male inherits an X chromosome carrying a recessive trait, he will express the trait because he does not have a second X chromosome to potentially mask the recessive gene.
Consider the genetic makeup of each option: A male with one X chromosome (XY), a male with two X chromosomes (XXY, which is a rare condition known as Klinefelter syndrome), a female with two X chromosomes (XX), and a female with one X chromosome (XO, which is a rare condition known as Turner syndrome).
Evaluate the likelihood of expressing an X-linked trait: A male with one X chromosome will express the trait if the X chromosome carries the gene, as there is no second X chromosome to counteract it. In contrast, females need two copies of the recessive gene to express the trait.
Conclude that a male with one X chromosome is more likely to express an X-linked trait because he only needs one copy of the gene on his single X chromosome to express the trait.
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