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Multiple Choice
How does the eukaryotic initiation complex locate the correct start codon during translation?
A
It recognizes the start codon by binding to the ribosome's A site.
B
It binds directly to the poly-A tail and locates the start codon.
C
It uses tRNA to identify the start codon by complementary base pairing.
D
It scans the mRNA from the 5' cap to the first AUG codon.
Verified step by step guidance
1
Understand the process of translation initiation in eukaryotes, which involves the assembly of the initiation complex at the 5' end of the mRNA.
Recognize that the eukaryotic initiation complex includes several components, such as the small ribosomal subunit, initiation factors, and the initiator tRNA.
Learn that the initiation complex first binds to the 5' cap of the mRNA, which is a modified guanine nucleotide that protects the mRNA and aids in ribosome binding.
The initiation complex then scans the mRNA in the 5' to 3' direction, looking for the start codon, which is typically the first AUG sequence encountered.
Once the initiation complex locates the AUG start codon, the large ribosomal subunit joins the complex, and translation begins with the initiator tRNA binding to the start codon in the P site of the ribosome.