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Multiple Choice
Where is dystrophin, the protein that is defective in muscular dystrophy, normally found?
A
In the extracellular matrix of connective tissue
B
Within the nucleus of neurons
C
Embedded in the mitochondrial inner membrane
D
Attached to the inner surface of muscle cell membranes (sarcolemma)
Verified step by step guidance
1
Understand the context of the question: Dystrophin is a protein associated with muscular dystrophy, a group of genetic disorders that affect muscle function. The question asks about its normal location in the body.
Recall the function of dystrophin: It plays a critical role in maintaining the structural integrity of muscle cells by connecting the cytoskeleton (actin filaments) inside the cell to the extracellular matrix through the sarcolemma (muscle cell membrane).
Eliminate incorrect options: Analyze each option provided. For example, dystrophin is not found in the extracellular matrix of connective tissue, within the nucleus of neurons, or embedded in the mitochondrial inner membrane. These locations are unrelated to dystrophin's role in muscle cells.
Identify the correct location: Dystrophin is attached to the inner surface of the sarcolemma (muscle cell membrane), where it helps stabilize the muscle cell during contraction and relaxation.
Conclude the reasoning: The correct answer is based on the biological role and location of dystrophin in muscle cells, which is essential for understanding its involvement in muscular dystrophy.