Multiple Choice
Which of the following best describes the role of a second messenger in cell signaling pathways?
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10. Cell Signaling
Introduction to Cell Signaling
Multiple Choice
Which of the following correctly labels the key components involved in the activation of a helper T cell by a dendritic cell?
A
MHC class I on dendritic cell, antigen peptide, B cell receptor (BCR) on helper T cell, and CD8 co-receptor
B
MHC class II on helper T cell, antigen peptide, T cell receptor (TCR) on dendritic cell, and CD8 co-receptor
C
MHC class II on dendritic cell, antigen peptide, T cell receptor (TCR) on helper T cell, and CD4 co-receptor
D
MHC class I on dendritic cell, antigen peptide, T cell receptor (TCR) on helper T cell, and CD4 co-receptor
Verified step by step guidance1
Step 1: Understand the context of the problem. Helper T cells are activated by antigen-presenting cells (APCs), such as dendritic cells, through a process involving specific molecular interactions. These interactions are crucial for initiating an immune response.
Step 2: Recall the role of MHC molecules. Major Histocompatibility Complex (MHC) molecules are proteins on the surface of APCs that present antigen peptides to T cells. MHC class II molecules are specifically involved in presenting antigens to helper T cells.
Step 3: Identify the components on the helper T cell. Helper T cells have T cell receptors (TCRs) that recognize the antigen peptide presented by MHC class II molecules. Additionally, the CD4 co-receptor on helper T cells stabilizes the interaction with MHC class II molecules.
Step 4: Eliminate incorrect options. For example, MHC class I molecules are involved in presenting antigens to cytotoxic T cells, not helper T cells. Similarly, CD8 co-receptors are associated with cytotoxic T cells, not helper T cells.
Step 5: Confirm the correct labeling. The correct components involved in the activation of a helper T cell by a dendritic cell are: MHC class II on the dendritic cell, antigen peptide, T cell receptor (TCR) on the helper T cell, and CD4 co-receptor.
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