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Multiple Choice
The direct energy source that drives ATP synthesis during respiratory oxidative phosphorylation is:
A
the breakdown of glucose into pyruvate
B
substrate-level phosphorylation of ADP
C
the transfer of electrons from NADH to oxygen
D
the proton (H\(^+\)) gradient across the inner mitochondrial membrane
Verified step by step guidance
1
Understand the process of oxidative phosphorylation, which occurs in the mitochondria during cellular respiration. It involves the electron transport chain and chemiosmosis.
Recognize that the electron transport chain creates a proton (H extsuperscript{+}) gradient across the inner mitochondrial membrane by pumping protons from the mitochondrial matrix into the intermembrane space.
Learn that this proton gradient represents potential energy, as the protons naturally want to flow back into the matrix due to the concentration and electrochemical gradient.
Understand that ATP synthase, a protein embedded in the inner mitochondrial membrane, uses the energy from the flow of protons (chemiosmosis) back into the matrix to catalyze the synthesis of ATP from ADP and inorganic phosphate (Pi).
Conclude that the direct energy source driving ATP synthesis during oxidative phosphorylation is the proton (H extsuperscript{+}) gradient across the inner mitochondrial membrane, not the breakdown of glucose, substrate-level phosphorylation, or electron transfer itself.