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Multiple Choice
Which of the following is the dominant method of carbon dioxide transport in the blood during cellular respiration?
A
Bound to hemoglobin as carbaminohemoglobin
B
As carbonic acid ($\mathrm{H_2CO_3}$) in red blood cells
C
Dissolved directly as $\mathrm{CO_2}$ gas in plasma
D
As bicarbonate ions ($\mathrm{HCO_3^-}$) dissolved in plasma
Verified step by step guidance
1
Step 1: Understand the context of the problem. Carbon dioxide ($\mathrm{CO_2}$) is a byproduct of cellular respiration and must be transported from tissues to the lungs for exhalation. The blood has several mechanisms to transport $\mathrm{CO_2}$ efficiently.
Step 2: Review the methods of $\mathrm{CO_2}$ transport in the blood. These include: (1) binding to hemoglobin as carbaminohemoglobin, (2) conversion to carbonic acid ($\mathrm{H_2CO_3}$) in red blood cells, (3) dissolving directly as $\mathrm{CO_2}$ gas in plasma, and (4) conversion to bicarbonate ions ($\mathrm{HCO_3^-}$) dissolved in plasma.
Step 3: Focus on the dominant method of $\mathrm{CO_2}$ transport. The majority of $\mathrm{CO_2}$ is transported as bicarbonate ions ($\mathrm{HCO_3^-}$). This occurs through a chemical reaction catalyzed by the enzyme carbonic anhydrase in red blood cells: $\mathrm{CO_2 + H_2O \rightarrow H_2CO_3 \rightarrow H^+ + HCO_3^-}$. The bicarbonate ions then diffuse into the plasma for transport.
Step 4: Compare the other methods of $\mathrm{CO_2}$ transport. While some $\mathrm{CO_2}$ binds to hemoglobin as carbaminohemoglobin and a small amount dissolves directly in plasma, these methods are less significant compared to the conversion to bicarbonate ions.
Step 5: Conclude that the dominant method of $\mathrm{CO_2}$ transport in the blood during cellular respiration is as bicarbonate ions ($\mathrm{HCO_3^-}$) dissolved in plasma. This mechanism is efficient and plays a critical role in maintaining blood pH balance.