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Multiple Choice
Which specific cytoskeletal element is most susceptible to mitotic inhibitors during cell division?
A
Intermediate filaments
B
Myosin filaments
C
Microtubules
D
Actin filaments (microfilaments)
Verified step by step guidance
1
Understand the role of cytoskeletal elements in cell division. The cytoskeleton is composed of microtubules, actin filaments (microfilaments), intermediate filaments, and other associated proteins. Each plays a distinct role in maintaining cell structure and facilitating cellular processes.
Focus on microtubules, as they are critical for mitosis. Microtubules form the mitotic spindle, which is responsible for separating chromosomes during cell division. Their dynamic nature (polymerization and depolymerization) makes them essential for proper mitotic function.
Learn about mitotic inhibitors. These are drugs or compounds that disrupt microtubule dynamics, preventing the formation or function of the mitotic spindle. Examples include taxanes (which stabilize microtubules) and vinca alkaloids (which prevent microtubule polymerization).
Compare the susceptibility of other cytoskeletal elements. Intermediate filaments provide structural support but are not directly involved in chromosome separation during mitosis. Actin filaments (microfilaments) play a role in cytokinesis (cell division's final step) but are less affected by mitotic inhibitors targeting microtubules.
Conclude that microtubules are the most susceptible cytoskeletal element to mitotic inhibitors during cell division due to their essential role in forming the mitotic spindle and their dynamic nature, which is targeted by these inhibitors.