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Multiple Choice
The end of a growing microtubule is rich in which type of tubulin subunit?
A
GTP-bound β-tubulin
B
GDP-bound α-tubulin
C
ADP-bound β-tubulin
D
GTP-bound α-tubulin
Verified step by step guidance
1
Understand the structure of microtubules: Microtubules are dynamic polymers made of tubulin subunits, specifically α-tubulin and β-tubulin, which form heterodimers. These dimers assemble into protofilaments that make up the microtubule.
Learn about the role of GTP and GDP in tubulin dynamics: Tubulin subunits bind guanine nucleotides (GTP or GDP). The β-tubulin subunit is capable of hydrolyzing GTP to GDP, while α-tubulin binds GTP but does not hydrolyze it.
Recognize the importance of GTP-bound β-tubulin: At the growing end of a microtubule, the β-tubulin subunits are typically GTP-bound. This GTP cap stabilizes the microtubule and promotes polymerization.
Understand the concept of dynamic instability: Microtubules undergo phases of growth and shrinkage. Loss of the GTP cap (conversion of GTP-bound β-tubulin to GDP-bound β-tubulin) leads to destabilization and depolymerization.
Review the options provided: Based on the above information, identify that the growing end of a microtubule is rich in GTP-bound β-tubulin, as this is essential for microtubule stability and elongation.