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Multiple Choice
In RNA interference, which molecule is responsible for silencing mRNA?
A
siRNA
B
mRNA
C
rRNA
D
tRNA
Verified step by step guidance
1
Understand the concept of RNA interference: RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression or translation by neutralizing targeted mRNA molecules.
Identify the types of RNA involved in cellular processes: mRNA (messenger RNA), rRNA (ribosomal RNA), tRNA (transfer RNA), and siRNA (small interfering RNA).
Focus on siRNA: siRNA is a class of double-stranded RNA molecules, typically 20-25 base pairs in length, that play a key role in the RNAi pathway.
Learn how siRNA functions: siRNA binds to a protein complex called RISC (RNA-induced silencing complex). This complex then uses one strand of the siRNA to bind to complementary sequences on the target mRNA.
Understand the outcome: Once bound, the RISC complex cleaves the mRNA, leading to its degradation and preventing translation, effectively silencing the gene.