Multiple Choice
What is meant by substrate-level phosphorylation?
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8. Respiration
Types of Phosphorylation
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Substrate-level phosphorylation is utilized to create ATP in which steps of aerobic cellular respiration?
A
Electron Transport Chain and Chemiosmosis.
B
Glycolysis and Pyruvate Oxidation.
C
Pyruvate Oxidation and Krebs cycle.
D
Glycolysis and Krebs cycle.
Verified step by step guidance1
Understand that substrate-level phosphorylation is a process of ATP generation that occurs directly in the metabolic pathway by transferring a phosphate group to ADP from a phosphorylated intermediate.
Recall that aerobic cellular respiration consists of several stages: Glycolysis, Pyruvate Oxidation, Krebs Cycle (Citric Acid Cycle), and Electron Transport Chain with Chemiosmosis.
Identify that substrate-level phosphorylation occurs in the cytoplasm during Glycolysis and in the mitochondrial matrix during the Krebs Cycle.
Note that in Glycolysis, substrate-level phosphorylation occurs when a phosphate group is transferred from 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate.
Recognize that in the Krebs Cycle, substrate-level phosphorylation occurs when a phosphate group is transferred from succinyl-CoA to ADP (or GDP), forming ATP (or GTP) and succinate.
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