Multiple Choice
Which of the following is responsible for recognizing the ER signal sequence?
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13. Intracellular Protein Transport
ER Processing and Transport
Multiple Choice
In eukaryotic cells, what is the primary function of the rough endoplasmic reticulum (rough ER)?
A
Synthesis and initial processing (folding and modification) of proteins destined for secretion, membranes, or lysosomes
B
Detoxification of drugs and synthesis of most membrane lipids
C
ATP production through oxidative phosphorylation
D
Storage of genetic information and regulation of transcription
Verified step by step guidance1
Identify the rough endoplasmic reticulum (rough ER) as an organelle characterized by the presence of ribosomes on its surface, which gives it a 'rough' appearance under a microscope.
Understand that ribosomes attached to the rough ER are the sites of protein synthesis, specifically for proteins that will be secreted from the cell, incorporated into cellular membranes, or sent to lysosomes.
Recognize that after synthesis, these proteins undergo initial processing such as folding and post-translational modifications within the rough ER to ensure proper function.
Differentiate the rough ER from other organelles: the smooth ER is involved in lipid synthesis and detoxification, mitochondria handle ATP production, and the nucleus stores genetic information and regulates transcription.
Conclude that the primary function of the rough ER is the synthesis and initial processing of proteins destined for secretion, membranes, or lysosomes.
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