Multiple Choice
Glycosylation of proteins in the ER is associated with which of the following molecules or responses?
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13. Intracellular Protein Transport
ER Processing and Transport
Multiple Choice
In the context of ER processing and transport, the rough endoplasmic reticulum (RER) appears “rough” because its cytosolic surface is studded with which structures?
A
Ribosomes engaged in translation
B
Clathrin-coated pits that mediate endocytosis
C
Proteasomes responsible for cytosolic protein degradation
D
COPII-coated vesicles permanently attached to the membrane
Verified step by step guidance1
Recall the structural features of the rough endoplasmic reticulum (RER) and what distinguishes it from the smooth endoplasmic reticulum (SER).
Understand that the 'rough' appearance of the RER is due to the presence of specific structures attached to its cytosolic surface.
Identify that these structures are involved in protein synthesis, specifically translating mRNA into polypeptide chains.
Recognize that ribosomes are the cellular organelles responsible for translation and that when they are bound to the ER membrane, they give it a 'rough' texture under the microscope.
Eliminate other options by recalling their functions and locations: clathrin-coated pits are involved in endocytosis at the plasma membrane, proteasomes degrade proteins in the cytosol, and COPII-coated vesicles are involved in transport but are not permanently attached to the RER membrane.
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