Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

17. Mutation, Repair, and Recombination

Types of Mutations

Genetics

17. Mutation, Repair, and Recombination

Types of Mutations

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2:24 minutes

Problem C.1b

Textbook Question

Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
c-MYC(Burkitt lymphoma)

Verified step by step guidance

Understand that c-MYC is a proto-oncogene, which means its normal function is to regulate cell growth and division by encoding a transcription factor that controls the expression of genes involved in cell cycle progression.

Recognize that in normal cells, c-MYC helps promote controlled cell proliferation and apoptosis, maintaining a balance necessary for healthy tissue function.

Note that mutations or translocations involving c-MYC, such as those seen in Burkitt lymphoma, lead to its overexpression, causing uncontrolled cell division and contributing to cancer development.

Summarize that the normal function of c-MYC is to act as a regulator of gene expression that promotes cell growth, differentiation, and apoptosis under tight control.

Conclude that understanding the normal role of c-MYC helps explain how its dysregulation through mutation or translocation can lead to oncogenesis.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Oncogenes and Proto-oncogenes

Proto-oncogenes are normal genes that regulate cell growth and division. When mutated or abnormally expressed, they become oncogenes that can promote uncontrolled cell proliferation, leading to cancer. Understanding the role of proto-oncogenes like c-MYC is essential to grasp how their mutations contribute to tumor development.

Function of c-MYC Gene

The c-MYC gene encodes a transcription factor that regulates the expression of genes involved in cell cycle progression, metabolism, and apoptosis. Normally, c-MYC controls cell growth and proliferation, but its overexpression or mutation can drive oncogenesis, as seen in Burkitt lymphoma.

Molecular Basis of Burkitt Lymphoma

Burkitt lymphoma is characterized by a chromosomal translocation involving c-MYC, leading to its deregulated expression. This translocation places c-MYC under the control of immunoglobulin gene enhancers, causing excessive cell proliferation in B lymphocytes and contributing to cancer development.

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Multiple Choice

A mutation occurred that changed the sequence 5' AAGCTTGC 3' to 5' AAGCTTTGC 3'. What is the name for this type of mutation?

Which of the following mutations changes one codon to a chemically different amino acid?

Which of the following point mutations changes a purine nucleotide to a pyrminidine nucleotide?

Changes in the codon reading frame can be caused from all but which of the following?

Identify the normal functions of the following genes whose mutations are associated with the development of cancer.

APC(familial adenomatous polyposis)

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Textbook Question

Identify the normal functions of the following genes whose mutations are associated with the development of cancer.

Which of these genes would you classify as a proto-oncogene and which as a tumor suppressor gene? Explain your categorization for each gene.

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Textbook Question

Identify the normal functions of the following genes whose mutations are associated with the development of cancer.

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Textbook Question

Identify the normal functions of the following genes whose mutations are associated with the development of cancer.

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Identify the normal functions of the following genes whose mutations are associated with the development of cancer.c-MYC(Burkitt lymphoma)

Key Concepts

Oncogenes and Proto-oncogenes

Function of c-MYC Gene

Molecular Basis of Burkitt Lymphoma

Watch next

Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
c-MYC(Burkitt lymphoma)