Textbook Question
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
c-MYC(Burkitt lymphoma)
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Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
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Sanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblem C.1d
Sanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblem C.1dChapter 14, Problem C.1d
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
APC(familial adenomatous polyposis)
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Understand that the APC gene is a tumor suppressor gene, which means its normal function is to regulate cell growth and prevent uncontrolled cell division.
Recognize that the APC protein plays a crucial role in the Wnt signaling pathway, where it helps regulate the levels of β-catenin, a protein involved in gene transcription that promotes cell proliferation.
Note that the APC protein forms a complex that targets β-catenin for degradation, thus preventing excessive cell growth and maintaining normal tissue homeostasis.
Realize that mutations in the APC gene disrupt this regulatory function, leading to accumulation of β-catenin and uncontrolled cell division, which contributes to the formation of familial adenomatous polyposis and increases cancer risk.
Summarize that the normal function of the APC gene is to act as a gatekeeper by controlling cell proliferation through the degradation of β-catenin, thereby preventing tumor development.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Tumor Suppressor Genes
Tumor suppressor genes produce proteins that regulate cell growth and division, preventing uncontrolled proliferation. When these genes mutate, their regulatory function is lost, leading to increased cancer risk. APC is a classic example of a tumor suppressor gene involved in colorectal cancer.
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Mapping Genes
APC Gene Function
The APC gene encodes a protein that helps regulate cell adhesion and signal transduction pathways, particularly the Wnt signaling pathway. It controls the degradation of beta-catenin, preventing excessive cell proliferation. Mutations in APC disrupt this control, promoting tumor formation in the colon.
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Familial Adenomatous Polyposis (FAP)
FAP is an inherited disorder caused by germline mutations in the APC gene, leading to the development of hundreds to thousands of colorectal polyps. Without intervention, these polyps have a high likelihood of progressing to colorectal cancer, highlighting the importance of APC in maintaining normal colon cell growth.
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Related Practice
Textbook Question
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
Which of these genes would you classify as a proto-oncogene and which as a tumor suppressor gene? Explain your categorization for each gene.
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Textbook Question
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
RB1(retinoblastoma)
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Textbook Question
You conduct a study in which the transcriptional fusion of regulatory sequences of a particular gene with a reporter gene results in relatively uniform expression of the reporter gene in all cells of an organism. A translational fusion with the same gene shows reporter gene expression only in the nucleus of a specific cell type. Discuss some biological causes for the difference in expression patterns of the two transgenes.
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Textbook Question
A tumor is a growing mass of abnormal cells. Give an example from this chapter of a benign tumor that becomes a malignant tumor.
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Textbook Question
A tumor is a growing mass of abnormal cells. What must happen for a benign tumor to become malignant?
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