Identify the normal functions of the following genes whose mut...

Question

Identify the normal functions of the following genes whose mutations are associated with the development of cancer.

APC(familial adenomatous polyposis)

Accepted Answer

Hi, everyone. Welcome back. Let's look at our next question. The A PC protein is a tumor suppressor gene that keeps cells from growing and dividing in an uncontrolled way. Mutations in the A PC gene are associated with which are the following diseases. Choice. A familial hyper cholemia, choice B, familial adenitis, polyposis, choice, C achondroplasia, choice D myotonic dystrophy. Well, we've got a mouthful here on some of these, but we're thinking about diseases that might be associated with mutations in a tumor suppressor gene. So we're gonna expect this to be diseases that cause tumors or cancers. So even if we can't remember off the top of our head, we might be able to rule out some more similar or more familiar sounding diseases that are not, you would not expect to be associated with mutations in a tumor suppressor gene. So, choice, a familial hyper cholesterol Leia or we can just say high cholesterol linked to genetics uh is obviously not something you'd expect to be linked to a tumor suppressor gene. And indeed, that is not the correct choice. Uh familial high cholesterol is due to mutations in the L D L receptor gene which makes sense. And then to see achondroplasia, you might recognize as a form of genetic dwarfism. Um Also not what we're looking for, as you might expect. It's caused by a mutation in the gene for a fibroblast growth factor. Three. And then if you're familiar with the what uh dystrophy is, we have to d myotonic dystrophy. A dystrophy is when you have a gradual breakdown of tissues. So not associated with uncontrolled growth and division. So choice d so we actually can eliminate these other choices. Um Oh and my myotonic dystrophy is caused by a mutation in the D MP K gene. In case you're curious. So we have just one left and familial anoti adenomatous polyposis is indeed the condition caused by a mutation in the A PC protein. And this might not immediately trigger something in our mind, but this causes the formation of polyps. And we can see that root word polyp in there in the colon and of course, pulps often go into, go on to develop into colon cancer. So that is a cancer associated disease that you might expect to result from a problem with a tumor suppressor gene. So again, mutations in the A PC gene associated with choice B, familial A adenomatous polyposis. See you in the next video.

Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
APC(familial adenomatous polyposis)

Key Concepts

Tumor Suppressor Genes

APC Gene Function

Familial Adenomatous Polyposis (FAP)

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