Multiple Choice
Which type of DNA mutation results in a change in the reading frame of an mRNA?
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17. Mutation, Repair, and Recombination
Types of Mutations
Multiple Choice
In the context of gene mutations, what type of mutation typically causes translation of an mRNA to stop prematurely by creating a stop codon within the coding sequence?
A
Missense mutation
B
Inversion mutation
C
Silent (synonymous) mutation
D
Nonsense mutation
Verified step by step guidance1
Understand the types of mutations and their effects on the protein sequence: Missense mutations change one amino acid to another, silent mutations do not change the amino acid sequence, and inversion mutations rearrange a segment of DNA without necessarily affecting the coding sequence directly.
Recall that a nonsense mutation is a point mutation in the DNA sequence that changes a codon encoding an amino acid into a stop codon.
Recognize that the introduction of a premature stop codon during translation causes the ribosome to stop protein synthesis early, resulting in a truncated and usually nonfunctional protein.
Identify that this premature termination of translation is the hallmark of a nonsense mutation, distinguishing it from missense, silent, or inversion mutations.
Conclude that the mutation type causing early translation termination by creating a stop codon within the coding sequence is a nonsense mutation.
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