Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

17. Mutation, Repair, and Recombination

DNA Repair

Genetics

17. Mutation, Repair, and Recombination

DNA Repair

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Multiple Choice

The overall error rate in the completed DNA molecule after replication and repair is approximately __________.

1 error per 10^3 nucleotides

1 error per 10^6 nucleotides

1 error per 10^9 nucleotides

1 error per 10^12 nucleotides

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Verified step by step guidance

Understand that DNA replication involves multiple steps that contribute to the overall fidelity, including the base-pairing accuracy of DNA polymerase, the proofreading activity of DNA polymerase, and the post-replication mismatch repair system.

Recognize that the initial error rate of DNA polymerase without proofreading is about 1 error per 10^5 nucleotides incorporated due to incorrect base pairing.

Consider that the proofreading function of DNA polymerase reduces this error rate by about 100-fold, improving accuracy to approximately 1 error per 10^7 nucleotides.

Acknowledge that the mismatch repair system further corrects errors missed by proofreading, enhancing fidelity by another 100- to 1000-fold, leading to a final error rate around 1 error per 10^9 nucleotides.

Combine these sequential error-correcting steps conceptually to understand why the overall error rate after replication and repair is approximately 1 error per 10^9 nucleotides.