It is estimated that about 0.2 percent of human mutations are due to TE insertions, and a much higher degree of mutational damage is known to occur in some other organisms. In what way might a TE insertion contribute positively to evolution?
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
16. Transposable Elements
Transposable Elements in Eukaryotes
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What would be the most likely consequence if a transposon inserts into the coding region of a gene, as indicated by the red arrow?
A
No effect on the gene or its expression
B
Disruption of gene function, potentially resulting in a loss-of-function mutation
C
Conversion of the gene into a non-coding RNA
D
Increased expression of the gene due to enhanced promoter activity

1
Understand what a transposon is: a DNA sequence that can change its position within the genome, potentially disrupting normal gene function.
Recognize that the coding region of a gene contains the sequence that is translated into protein, so any insertion here can alter the protein product.
Consider that insertion of a transposon into the coding region can disrupt the reading frame or introduce premature stop codons, leading to a loss-of-function mutation.
Evaluate why other options are less likely: no effect is unlikely because coding regions are critical; conversion into non-coding RNA is not a typical consequence of transposon insertion; increased expression due to enhanced promoter activity would require insertion near regulatory regions, not within coding sequences.
Conclude that the most likely consequence is disruption of gene function, potentially resulting in a loss-of-function mutation.
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