Multiple Choice
In both prokaryotes and eukaryotes, gene regulation most commonly occurs at which stage of gene expression?
3
views
13. Gene Regulation in Eukaryotes
Overview of Eukaryotic Gene Regulation
Struggling with Genetics?
Join thousands of students who trust us to help them ace their exams!Watch the first videoMultiple Choice
Which component of the RNA polymerase holoenzyme is responsible for recognizing the promoter in eukaryotic gene regulation?
A
Mediator complex
B
RNA polymerase II core enzyme
C
General transcription factor (TFIID)
D
Sigma factor
Verified step by step guidance1
Understand the components involved in eukaryotic transcription initiation. The RNA polymerase holoenzyme in eukaryotes includes RNA polymerase II and several general transcription factors (GTFs).
Recall that the core RNA polymerase II enzyme itself does not directly recognize promoter sequences; instead, it requires accessory proteins to locate the promoter.
Identify the role of general transcription factors, especially TFIID, which contains the TATA-binding protein (TBP) that specifically recognizes and binds to the TATA box within the promoter region.
Differentiate this from the sigma factor, which is a bacterial protein responsible for promoter recognition in prokaryotes, not eukaryotes.
Note that the mediator complex acts as a bridge between transcription factors and RNA polymerase II but does not directly recognize the promoter sequence.
Related Videos
Related Practice
Overview of Eukaryotic Gene Regulation practice set
Problem sets built by lead tutorsExpert video explanations