Multiple Choice
In the context of eukaryotic gene regulation, CpG islands are generally associated with which of the following gene states?
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13. Gene Regulation in Eukaryotes
Overview of Eukaryotic Gene Regulation
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For eukaryotic protein-encoding genes, what is the core promoter?
A
A region of DNA located far upstream from the gene that enhances transcription by binding activator proteins.
B
A segment of DNA that silences gene expression by recruiting repressor proteins.
C
A sequence of DNA that codes for the amino acid sequence of a protein.
D
A DNA sequence that includes the TATA box and transcription start site, serving as the binding site for general transcription factors and RNA polymerase II.
Verified step by step guidance1
Understand that the core promoter is a specific DNA region crucial for initiating transcription in eukaryotic protein-encoding genes.
Recognize that the core promoter includes key elements such as the TATA box and the transcription start site, which are essential for the assembly of the transcription machinery.
Know that general transcription factors bind to the core promoter to help position RNA polymerase II correctly at the start site of transcription.
Distinguish the core promoter from other regulatory regions like enhancers (which are located far upstream and bind activators) and silencers (which recruit repressors to inhibit transcription).
Summarize that the core promoter acts as the fundamental platform where transcription begins, enabling RNA polymerase II to start synthesizing RNA from the DNA template.
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