A person has a WT chromosome with the following segments. A B C • D E F G H. Which of the following shows how the chromosome would look after an paracentric inversion?

A couple planning their family are aware that through the past three generations on the husband's side a substantial number of stillbirths have occurred and several malformed babies were born who died early in childhood. The wife has studied genetics and urges her husband to visit a genetic counseling clinic, where a complete karyotype-banding analysis is performed. Although the tests show that he has a normal complement of 46 chromosomes, banding analysis reveals that one member of the chromosome 1 pair (in group A) contains an inversion covering 70 percent of its length. The homolog of chromosome 1 and all other chromosomes show the normal banding sequence. How would you explain the high incidence of past stillbirths?

In the tomato, Solanum esculentum, tall (D−)(D−) is dominant to dwarf (dd) plant height, smooth fruit (P−) is dominant to peach fruit (pp), and round fruit shape (O−) is dominant to oblate fruit shape (oo). These three genes are linked on chromosome 1 of tomato in the order dwarf–peach–oblate. There are 12 map units between dwarf and peach and 17 map units between peach and oblate. A trihybrid plant (DPO/dpo) is test-crossed to a plant that is homozygous recessive at the three loci (dpo/dpo). The accompanying table shows the progeny plants. Identify the mechanism responsible for the resulting data that do not agree with the established genetic map.

A pair of homologous chromosomes in Drosophila has the following content (single letters represent genes):

Chromosome 1RNMDHBGKWU

Chromosome 2RNMDHBDHBGKWU

How does the pairing diagrammed in part (b) differ from the pairing of chromosomes in an inversion heterozygote?

A person has a WT chromosome with the following segments. A B C • D E F G H. Which of the following shows how the chromosome would look after a pericentric inversion?

From the following list, identify the types of chromosome changes you expect to show phenotypic consequences.

Pericentric inversion

Inversions are said to 'suppress crossing over.' Is this terminology technically correct? If not, restate the description accurately.

Contrast the genetic composition of gametes derived from tetrads of inversion heterozygotes where crossing over occurs within a paracentric versus a pericentric inversion.