Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

17. Mutation, Repair, and Recombination

DNA Repair

Genetics

17. Mutation, Repair, and Recombination

DNA Repair

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Multiple Choice

Which of the following repair pathways repairs damage that causes distortions in the double helix?

Base Excision Repair

Nucleotide Excision Repair

Mismatch Repair

Homologous Recombination

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Verified step by step guidance

Understand the types of DNA damage: Distortions in the double helix are often caused by bulky adducts or thymine dimers, which are typically the result of UV radiation or chemical exposure.

Identify the repair mechanisms: Different repair pathways are specialized for different types of DNA damage. Base Excision Repair (BER) fixes small, non-helix-distorting base lesions. Mismatch Repair (MMR) corrects base mismatches that occur during DNA replication. Homologous Recombination (HR) is involved in repairing double-strand breaks.

Focus on Nucleotide Excision Repair (NER): This pathway is specifically designed to remove bulky DNA adducts and thymine dimers that cause significant distortions in the DNA double helix.

NER process overview: NER involves the recognition of the distortion, excision of a short single-stranded DNA segment containing the lesion, and synthesis of a new DNA strand using the undamaged strand as a template.

Conclude with the correct pathway: Given the nature of the damage (distortions in the double helix), Nucleotide Excision Repair is the appropriate repair mechanism.