Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
4. Genetic Mapping and Linkage
Multiple Cross Overs and Interference
Problem 14c
Textbook Question
In Drosophila, a cross was made between females—all expressing the three X-linked recessive traits scute bristles (sc), sable body (s), and vermilion eyes (v)—and wild-type males. In the F1, all females were wild type, while all males expressed all three mutant traits. The cross was carried to the F2 generation, and 1000 offspring were counted, with the results shown in the following table.

No determination of sex was made in the data.
Are there more or fewer double crossovers than expected?

1
Step 1: Identify the parental phenotypes and offspring phenotypes. Parental phenotypes are sc s v (mutant) and + + + (wild type). The offspring phenotypes include combinations of these traits, as listed in the table.
Step 2: Determine the recombination frequencies for each pair of genes. Use the offspring counts to calculate the number of single crossovers and double crossovers. For example, single crossovers between sc and s can be identified by phenotypes like sc + + and + s v.
Step 3: Calculate the expected number of double crossovers using the product of the recombination frequencies between sc-s and s-v. Multiply the total number of offspring (1000) by this expected frequency.
Step 4: Compare the observed number of double crossovers (phenotypes sc s + and + + v) to the expected number. Observed double crossovers are the sum of offspring counts for these phenotypes.
Step 5: Analyze whether the observed number of double crossovers is greater or fewer than expected. This comparison will help determine if interference is present in the genetic map.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
X-linked Inheritance
X-linked inheritance refers to the pattern of inheritance for genes located on the X chromosome. In Drosophila, males have one X chromosome and one Y chromosome, while females have two X chromosomes. This means that recessive traits on the X chromosome will be expressed in males if present, while females may be carriers if they have one normal allele and one recessive allele.
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Genetic Mapping and Recombination
Genetic mapping involves determining the relative positions of genes on a chromosome based on recombination frequencies. Recombination occurs during meiosis when homologous chromosomes exchange genetic material. The frequency of double crossovers can be calculated to assess the distance between genes, which is crucial for understanding the inheritance patterns observed in the offspring.
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Mapping Genes
Phenotypic Ratios and Chi-Square Analysis
Phenotypic ratios represent the relative frequencies of different phenotypes in the offspring resulting from a genetic cross. In this context, a chi-square analysis can be used to compare the observed offspring counts with the expected counts based on Mendelian ratios. This statistical method helps determine if the deviations from expected ratios are significant, indicating potential double crossovers or other genetic phenomena.
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Multiple Choice
The term 'multiple alleles' refers to the presence of how many or more alleles in the population?
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