BackMatch each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.
The probability that the healthy brother of a woman with an autosomal recessive condition is a heterozygous carrier
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.
A person who on the basis of family history must be a heterozygous carrier of a recessive mutant allele
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.
The Mendelian risk that a person is a heterozygous carrier of a recessive condition
Albinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.)
Construct a pedigree of the families in (b) and (c). Assume that one of the normal children in (b) and one of the albino children in (c) become the parents of eight children. Add these children to the pedigree, predicting their phenotypes (normal or albino).
Albinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.)
A normal male and an albino female have six children, three normal and three albino.
Albinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.)
A normal male and an albino female have six children, all normal.
Albinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.)
Two normal parents have five children: four normal and one albino.
A couple comes into your genetic counseling practice with a question about the chance a future child of theirs might have a genetic disease. Three or four men in the woman's family, including her father, had a condition that might be genetic. Although her father is still alive, she has had little contact with him for much of her life and cannot describe or name the condition. Her partner is a healthy man whose family has no history indicating the presence of a genetic condition. To provide more information about this possible genetic condition for the couple, what is the first step you recommend?
In mice, black coat color is dominant to white coat color. In the pedigree shown here, mice with a black coat are represented by darkened symbols, and those with white coats are shown as open symbols. Using allele symbols B and b, determine the genotypes for each mouse.
Nail–patella syndrome is an autosomal disorder affecting the shape of nails on fingers and toes as well as the structure of kneecaps. The pedigree below shows the transmission of nail–patella syndrome in a family along with ABO blood type.
Explain why III-11 has nail–patella syndrome and III-12 does not. Give genotypes for these two individuals.
Nail–patella syndrome is an autosomal disorder affecting the shape of nails on fingers and toes as well as the structure of kneecaps. The pedigree below shows the transmission of nail–patella syndrome in a family along with ABO blood type.
Does this family give evidence of genetic linkage between nail–patella syndrome and ABO blood group? Why or why not?
Nail–patella syndrome is an autosomal disorder affecting the shape of nails on fingers and toes as well as the structure of kneecaps. The pedigree below shows the transmission of nail–patella syndrome in a family along with ABO blood type. Is nail–patella syndrome a dominant or a recessive condition?
Is nail–patella syndrome a dominant or a recessive condition? Explain your reasoning.
Mendel crossed peas having green seeds with peas having yellow seeds. The F₁ generation produced only yellow seeds. In the F₂, the progeny consisted of 6022 plants with yellow seeds and 2001 plants with green seeds. Of the F₂ yellow-seeded plants, 519 were self-fertilized with the following results: 166 bred true for yellow and 353 produced an F₃ ratio of 3/4 yellow: 1/4 green. Explain these results by diagramming the crosses.
Nail–patella syndrome is an autosomal disorder affecting the shape of nails on fingers and toes as well as the structure of kneecaps. The pedigree below shows the transmission of nail–patella syndrome in a family along with ABO blood type.
Explain why III-6 has nail–patella syndrome and III-8 does not. Give genotypes for these two individuals.
Nail–patella syndrome is an autosomal disorder affecting the shape of nails on fingers and toes as well as the structure of kneecaps. The pedigree below shows the transmission of nail–patella syndrome in a family along with ABO blood type.
Using N and n to represent alleles at the nail–patella locus and Iᴬ, Iᴮ and i to represent ABO alleles, write the genotypes of I-1 and I-2 as well as their five children in generation II.