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Nutrient Absorption and Transport
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Nutrient Absorption and Transport
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3. The Human Body & Digestion / Nutrient Absorption and Transport / Problem 4
Problem 4
If a new drug is highly lipophilic and small, what absorption modification would most increase its rate of passive uptake across enterocytes?
A
Administering it with a competitive polar nutrient that uses the same channel, since channel competition enhances passive uptake across bilayers.
B
Adding a large charged moiety to the molecule to increase its water solubility so it will dissolve in the lumen and be absorbed faster by passive diffusion.
C
Co-administering it with a fatty meal to enhance its solubilization and partitioning into the lipid bilayer, increasing passive absorption.
D
Blocking all lacteals so lipophilic molecules cannot enter lymph and therefore will be forced to diffuse directly into portal capillaries.
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