which-property-of-a-molecule-most-strongly-predicts-its-ability-to-cross-the-int

Question

Which property of a molecule most strongly predicts its ability to cross the intestinal epithelial cell membrane by passive diffusion?

Accepted Answer

Lipid solubility (nonpolarity) and small molecular size.

Answer

Ability to form covalent bonds with membrane phospholipids and thereby be carried across.

Answer

Presence of multiple hydroxyl groups that create extensive hydrogen bonding with the interior of the lipid bilayer.

Answer

High molecular weight and strong ionic charge that enhances attraction to membrane lipids.