Table of contents

1. A Review of General Chemistry5h 5m
2. Molecular Representations1h 14m
3. Acids and Bases2h 46m
4. Alkanes and Cycloalkanes4h 17m
5. Chirality3h 39m
6. Thermodynamics and Kinetics1h 22m
7. Substitution Reactions1h 48m
8. Elimination Reactions2h 30m
9. Alkenes and Alkynes2h 9m
10. Addition Reactions3h 19m
11. Radical Reactions1h 58m
12. Alcohols, Ethers, Epoxides and Thiols2h 42m
13. Alcohols and Carbonyl Compounds2h 17m
14. Synthetic Techniques1h 26m
15. Analytical Techniques:IR, NMR, Mass Spect7h 3m
16. Conjugated Systems6h 13m
17. Ultraviolet Spectroscopy51m
18. Aromaticity2h 34m
19. Reactions of Aromatics: EAS and Beyond5h 1m
20. Phenols55m
21. Aldehydes and Ketones: Nucleophilic Addition4h 56m
22. Carboxylic Acid Derivatives: NAS2h 51m
23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides1h 10m
24. Enolate Chemistry: Reactions at the Alpha-Carbon1h 53m
25. Condensation Chemistry2h 9m
26. Amines1h 43m
27. Heterocycles2h 0m
28. Carbohydrates5h 53m
29. Amino Acids4h 20m
30. Peptides and Proteins2h 42m
31. Catalysis in Organic Reactions1h 30m
32. Lipids 2h 50m
33. The Organic Chemistry of Metabolic Pathways2h 52m
34. Nucleic Acids1h 32m
35. Transition Metals6h 14m
36. Synthetic Polymers1h 49m

34. Nucleic Acids

Intro to Nucleic Acids

Organic Chemistry

34. Nucleic Acids

Intro to Nucleic Acids

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Multiple Choice

In the process of mRNA maturation, what is necessary for the addition of the poly(A) tail?

5' cap structure

Polyadenylation signal sequence

Spliceosome complex

Ribosome binding site

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Verified step by step guidance

Understand the role of the poly(A) tail in mRNA maturation. The poly(A) tail is a stretch of adenine nucleotides added to the 3' end of an mRNA molecule, which helps in the stability and export of the mRNA from the nucleus.

Identify the key components involved in the addition of the poly(A) tail. The polyadenylation signal sequence is crucial for this process, as it signals where the poly(A) tail should be added.

Recognize the sequence that acts as the polyadenylation signal. This sequence is typically AAUAAA, located near the 3' end of the pre-mRNA, and is essential for the recruitment of the polyadenylation machinery.

Explore the role of the polyadenylation machinery. Once the polyadenylation signal sequence is recognized, a complex of proteins, including poly(A) polymerase, is recruited to cleave the pre-mRNA and add the poly(A) tail.

Consider the importance of the poly(A) tail in mRNA function. The addition of the poly(A) tail is a critical step in mRNA maturation, influencing mRNA stability, nuclear export, and translation efficiency.