a-pathology-image-shows-tumor-cells-breaching-the-basement-membrane-and-appearin

Question

A pathology image shows tumor cells breaching the basement membrane and appearing inside lymphatic channels near the primary mass. Using an invasion/metastasis framework, which immediate process is this specimen demonstrating, and what is the most likely next step for metastatic spread?

Accepted Answer

This demonstrates invasion; next, tumor cells can enter lymphatic vessels and be transported to regional lymph nodes where they may form secondary deposits.

Answer

This is a sign of necrosis; the cells are dead and therefore mark the end of the tumor’s ability to metastasize to any distant site.

Answer

This is cellular differentiation; tumor cells will revert to normal tissue types and be incorporated into surrounding structures rather than spreading.

Answer

This shows angiogenesis only; the tumor cells will remain localized because lymphatic channels lack flow and cannot move cells systemically.