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Multiple Choice
Which subunit of a heterotrimeric G protein binds GTP?
A
Gamma subunit
B
Delta subunit
C
Beta subunit
D
Alpha subunit
Verified step by step guidance
1
Understand the structure of heterotrimeric G proteins, which are composed of three subunits: alpha, beta, and gamma.
Recognize that the alpha subunit is responsible for binding guanine nucleotides, such as GDP (guanosine diphosphate) and GTP (guanosine triphosphate).
Learn that in the inactive state, the alpha subunit is bound to GDP. Upon activation by a receptor, GDP is exchanged for GTP.
Note that the binding of GTP to the alpha subunit causes a conformational change, leading to the dissociation of the alpha subunit from the beta and gamma subunits.
Conclude that the alpha subunit is the one that binds GTP, allowing it to interact with downstream effectors in the signaling pathway.