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Multiple Choice
What event initiates the intrinsic pathway of coagulation?
A
Exposure of blood to tissue factor
B
Activation of factor XII by contact with collagen
C
Release of platelet-derived growth factor
D
Conversion of fibrinogen to fibrin
Verified step by step guidance
1
Understand the intrinsic pathway of coagulation: It is one of the two pathways that lead to the formation of a blood clot, the other being the extrinsic pathway. The intrinsic pathway is initiated by damage to the blood vessel itself.
Identify the key event that initiates the intrinsic pathway: The intrinsic pathway begins when blood comes into contact with collagen exposed by damage to the blood vessel wall.
Recognize the role of factor XII: Factor XII, also known as Hageman factor, is activated when it comes into contact with collagen. This activation is the first step in the intrinsic pathway.
Differentiate between intrinsic and extrinsic pathways: The intrinsic pathway is activated by internal trauma to the vascular system, whereas the extrinsic pathway is initiated by external trauma that causes blood to escape from the vessel.
Connect the activation of factor XII to the coagulation cascade: Once factor XII is activated, it sets off a series of reactions involving other clotting factors, ultimately leading to the conversion of fibrinogen to fibrin, forming a stable blood clot.