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Multiple Choice
The thick ascending limb of the nephron loop is mostly permeable to:
A
Urea
B
Water
C
Sodium and chloride ions
D
Glucose
Verified step by step guidance
1
Step 1: Understand the structure and function of the nephron loop (loop of Henle). The nephron loop is divided into the descending limb and the ascending limb, each with distinct permeability characteristics.
Step 2: Recall that the thick ascending limb of the nephron loop is impermeable to water. This is a key feature that differentiates it from the descending limb, which is permeable to water.
Step 3: Note that the thick ascending limb actively transports sodium (Na⁺) and chloride (Cl⁻) ions out of the tubular fluid into the surrounding interstitial fluid. This process is essential for creating the concentration gradient in the kidney.
Step 4: Recognize that the thick ascending limb is not permeable to urea or glucose. These substances are handled differently in other parts of the nephron, such as the proximal tubule for glucose reabsorption.
Step 5: Conclude that the primary function of the thick ascending limb is to reabsorb sodium and chloride ions, contributing to the countercurrent multiplication mechanism that concentrates urine.