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Multiple Choice
During the Krebs Cycle, is there a net gain or loss of ATP when citrate is transported across the mitochondrial membrane?
A
Net gain of NADH
B
Net loss of ATP
C
No net gain or loss of ATP
D
Net gain of ATP
Verified step by step guidance
1
Understand the role of citrate in the Krebs Cycle: Citrate is an intermediate in the Krebs Cycle, which occurs in the mitochondrial matrix. It is formed from acetyl-CoA and oxaloacetate.
Consider the transport of citrate across the mitochondrial membrane: Citrate can be transported out of the mitochondria to the cytosol, where it can be used for fatty acid synthesis or other metabolic processes.
Evaluate the energy implications of citrate transport: The transport of citrate itself does not directly involve ATP consumption or production. However, the processes that utilize citrate in the cytosol may have different energy requirements.
Analyze the ATP balance in the Krebs Cycle: The Krebs Cycle itself produces ATP (or GTP) through substrate-level phosphorylation, but the transport of citrate does not alter this balance directly.
Conclude on the net ATP gain or loss: Since the transport of citrate does not directly affect ATP production or consumption, there is no net gain or loss of ATP specifically due to citrate transport across the mitochondrial membrane.