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Multiple Choice
Which of the following correctly lists the sequence of events during the excitation of a skeletal muscle fiber?
A
Acetylcholine is released → Action potential arrives at the neuromuscular junction → Action potential is generated in the muscle fiber → Acetylcholine binds to receptors on the sarcolemma
B
Acetylcholine binds to receptors on the sarcolemma → Action potential arrives at the neuromuscular junction → Acetylcholine is released → Action potential is generated in the muscle fiber
C
Action potential is generated in the muscle fiber → Acetylcholine is released → Action potential arrives at the neuromuscular junction → Acetylcholine binds to receptors on the sarcolemma
D
Action potential arrives at the neuromuscular junction → Acetylcholine is released → Acetylcholine binds to receptors on the sarcolemma → Action potential is generated in the muscle fiber
Verified step by step guidance
1
Step 1: Understand the sequence of events during skeletal muscle fiber excitation. This process involves communication between the nervous system and the muscle fiber at the neuromuscular junction.
Step 2: Recognize that the process begins with the arrival of an action potential at the neuromuscular junction. This electrical signal is transmitted from the motor neuron to the muscle fiber.
Step 3: Once the action potential reaches the neuromuscular junction, it triggers the release of acetylcholine (ACh), a neurotransmitter, from the synaptic vesicles in the motor neuron into the synaptic cleft.
Step 4: Acetylcholine then binds to specific receptors on the sarcolemma (the plasma membrane of the muscle fiber). This binding causes ion channels to open, leading to changes in the membrane potential.
Step 5: The change in membrane potential generates a new action potential in the muscle fiber, which initiates the contraction process. This sequence ensures proper communication and activation of the muscle fiber.