Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

7. Enzyme Inhibition and Regulation

Enzyme Inhibition

Biochemistry

7. Enzyme Inhibition and Regulation

Enzyme Inhibition

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Multiple Choice

Which of the following statements regarding glucose 6-phosphate dehydrogenase (G6PD) is incorrect?

G6PD deficiency can lead to increased susceptibility to oxidative stress.

G6PD activity is important for maintaining cellular levels of NADPH.

G6PD uses NADH as a cofactor to oxidize glucose 6-phosphate.

G6PD catalyzes the first step of the pentose phosphate pathway.

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Verified step by step guidance

Step 1: Begin by understanding the role of glucose 6-phosphate dehydrogenase (G6PD) in cellular metabolism. G6PD is an enzyme that catalyzes the first step of the pentose phosphate pathway, which is crucial for producing NADPH and ribose-5-phosphate.

Step 2: Recall the importance of NADPH in the cell. NADPH is a reducing agent that helps combat oxidative stress by maintaining the reduced state of glutathione, a key antioxidant molecule.

Step 3: Analyze the statements provided. The first statement, 'G6PD deficiency can lead to increased susceptibility to oxidative stress,' is correct because a lack of NADPH impairs the cell's ability to handle oxidative damage.

Step 4: Evaluate the second statement, 'G6PD activity is important for maintaining cellular levels of NADPH.' This is also correct, as G6PD is directly involved in generating NADPH through the pentose phosphate pathway.

Step 5: Examine the third statement, 'G6PD uses NADH as a cofactor to oxidize glucose 6-phosphate.' This is incorrect because G6PD uses NADP⁺, not NADH, as a cofactor to oxidize glucose 6-phosphate. This distinction is critical to understanding the enzyme's function in the pentose phosphate pathway.