Multiple Choice
During the process of proofreading, what type of enzymatic activity does DNA polymerase utilize?
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7. Enzyme Inhibition and Regulation
Enzyme Inhibition
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In the context of enzyme inhibition, transition state analogs are usually classified as which type of inhibitor?
A
Competitive inhibitors
B
Noncompetitive inhibitors
C
Allosteric inhibitors
D
Uncompetitive inhibitors
Verified step by step guidance1
Understand the concept of enzyme inhibition: Enzyme inhibitors are molecules that bind to enzymes and decrease their activity. Different types of inhibitors interact with enzymes in distinct ways.
Learn about transition state analogs: These are molecules that mimic the transition state of a substrate during an enzymatic reaction. They are designed to bind tightly to the enzyme's active site.
Recall the mechanism of competitive inhibition: Competitive inhibitors bind to the active site of the enzyme, preventing the substrate from binding. Transition state analogs often act as competitive inhibitors because they resemble the substrate's transition state and compete for the active site.
Differentiate competitive inhibitors from other types: Noncompetitive inhibitors bind to a site other than the active site and affect enzyme activity regardless of substrate binding. Allosteric inhibitors bind to regulatory sites and alter enzyme conformation. Uncompetitive inhibitors bind only to the enzyme-substrate complex, not the free enzyme.
Conclude that transition state analogs are classified as competitive inhibitors because they directly compete with the substrate for binding to the enzyme's active site.
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