Multiple Choice
In the citric acid (Krebs) cycle, why is the pathway considered a “cycle”?
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Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism
Citric Acid Cycle 1
Multiple Choice
In eukaryotic cells, where do the reactions of the tricarboxylic acid (TCA) cycle primarily take place?
A
Mitochondrial matrix
B
Cytosol
C
Nucleus
D
Mitochondrial intermembrane space
Verified step by step guidance1
Understand the location of the TCA cycle by recalling that it is a central metabolic pathway involved in energy production through the oxidation of acetyl-CoA.
Recall that eukaryotic cells have compartmentalized structures, and metabolic pathways are often localized to specific organelles.
Identify that the TCA cycle enzymes are located inside the mitochondria, but specifically within the mitochondrial matrix, which is the innermost compartment of the mitochondrion.
Recognize that the mitochondrial intermembrane space is the area between the inner and outer mitochondrial membranes and is not the site of the TCA cycle reactions.
Conclude that the TCA cycle primarily takes place in the mitochondrial matrix, where substrates and enzymes are present for the cycle to proceed efficiently.
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