Multiple Choice
In eukaryotic cells, where do the reactions of the citric acid (TCA) cycle primarily occur?
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Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism
Citric Acid Cycle 1
Multiple Choice
In eukaryotic cells, where does the Krebs (citric acid) cycle primarily take place?
A
Cytosol
B
Nucleus
C
Inner mitochondrial membrane (cristae)
D
Mitochondrial matrix
Verified step by step guidance1
Understand that the Krebs cycle, also known as the citric acid cycle, is a key metabolic pathway involved in cellular respiration, where acetyl-CoA is oxidized to produce energy-rich molecules.
Recall the structure of a eukaryotic cell, focusing on the mitochondrion, which has an outer membrane, an inner membrane (folded into cristae), and an internal space called the matrix.
Recognize that the Krebs cycle enzymes are located in the mitochondrial matrix, the innermost compartment of the mitochondrion, where the cycle takes place.
Differentiate this location from other cellular compartments: the cytosol (where glycolysis occurs), the nucleus (which houses DNA), and the inner mitochondrial membrane (site of the electron transport chain, not the Krebs cycle).
Conclude that the primary site of the Krebs cycle in eukaryotic cells is the mitochondrial matrix.
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