Multiple Choice
In oxidative phosphorylation, why does oxidation yield less ATP than oxidation?
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Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation
Oxidative Phosphorylation 1
Multiple Choice
In aerobic metabolism, which energy pathway produces the greatest amount of ATP per molecule of glucose?
A
Substrate-level phosphorylation in the citric acid cycle (e.g., GTP formation)
B
Fermentation (lactate or ethanol production)
C
Oxidative phosphorylation via the electron transport chain and chemiosmosis
D
Glycolysis
Verified step by step guidance1
Identify the main energy-producing pathways involved in aerobic metabolism: glycolysis, the citric acid cycle (including substrate-level phosphorylation), fermentation, and oxidative phosphorylation via the electron transport chain.
Recall that glycolysis produces a small net amount of ATP directly through substrate-level phosphorylation, generating 2 ATP molecules per glucose molecule.
Understand that the citric acid cycle also produces a small amount of ATP (or GTP) directly through substrate-level phosphorylation, but its main contribution is in generating reduced cofactors (NADH and FADH2) for the electron transport chain.
Recognize that fermentation pathways (such as lactate or ethanol production) regenerate NAD+ but do not produce additional ATP beyond glycolysis, and are typically anaerobic processes.
Conclude that oxidative phosphorylation, which uses the electron transport chain and chemiosmosis to convert the energy stored in NADH and FADH2 into ATP, produces the greatest amount of ATP per glucose molecule in aerobic metabolism.
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