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Multiple Choice
Most of the ATP produced during aerobic metabolism in eukaryotic cells is generated in which location/process?
A
Mitochondrial matrix via the citric acid cycle (TCA cycle) substrate-level phosphorylation
B
Cytosol via substrate-level phosphorylation during glycolysis
C
Mitochondrial inner membrane via oxidative phosphorylation (electron transport chain and ATP synthase)
D
Endoplasmic reticulum membrane via proton pumping coupled to ATP synthase
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Verified step by step guidance
1
Identify the main processes involved in ATP production during aerobic metabolism: glycolysis, the citric acid cycle (TCA cycle), and oxidative phosphorylation.
Recall that glycolysis occurs in the cytosol and produces a small amount of ATP via substrate-level phosphorylation.
Understand that the citric acid cycle takes place in the mitochondrial matrix and also produces ATP (or GTP) via substrate-level phosphorylation, but in limited amounts.
Recognize that the majority of ATP is generated by oxidative phosphorylation, which occurs at the mitochondrial inner membrane and involves the electron transport chain and ATP synthase.
Conclude that the mitochondrial inner membrane via oxidative phosphorylation is the primary site/process for ATP production during aerobic metabolism in eukaryotic cells.