Multiple Choice
Which steps of glycolysis are considered irreversible under physiological conditions (i.e., have a large negative )?
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Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway
Glycolysis 1
Multiple Choice
In aerobic glycolysis of one molecule of glucose to two molecules of pyruvate, what is the net production of ATP (accounting for ATP used and produced by substrate-level phosphorylation)?
A
ATP (net)
B
ATP (net)
C
ATP (net)
D
ATP (net)
Verified step by step guidance1
Identify the total number of ATP molecules consumed during the initial steps of glycolysis. Specifically, note that ATP is used in the phosphorylation of glucose and fructose-6-phosphate.
Determine the total number of ATP molecules produced during the later steps of glycolysis, particularly during substrate-level phosphorylation when 1,3-bisphosphoglycerate and phosphoenolpyruvate are converted to 3-phosphoglycerate and pyruvate, respectively.
Remember that glycolysis converts one molecule of glucose into two molecules of pyruvate, so multiply the ATP produced per molecule of substrate by 2 to account for both pyruvate molecules formed.
Calculate the net ATP production by subtracting the ATP consumed from the ATP produced: use the formula \(\text{Net ATP} = \text{ATP produced} - \text{ATP consumed}\).
Conclude the net ATP yield from glycolysis, which reflects the balance of ATP molecules used and generated through substrate-level phosphorylation.
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